Osteoprotegerin (TNFRSF11B) Mouse Monoclonal Antibody [Clone ID: 98A1071]

CAT#: TA336370

Mouse Monoclonal Osteoprotegerin/TNFRSF11B Antibody (98A1071)


 Product Datasheet for 'TA336370'

USD 415.00


Availability*
5 Days

Size
    • 0.1 mg


Specifications

Product Data
Clone Name 98A1071
Applications FC, IHC, WB
Recommend Dilution WB: 1 ug/ml, IF: 1:10-1:500, IHC: 1:10-1:500, IHC-F: 1:10-1:500, IHC-P: 1:10-1:500, IP: 1:10-1:500
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen A peptide corresponding to the amino acids 20-37 TQETFPPKYLHYDEETSH of human Osteoprotegerin was used as immunogen for this antibody.
Isotype IgG1 Kappa
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration 0.5 mg/ml
Purification Protein G purified
Gene Name tumor necrosis factor receptor superfamily member 11b
Background Osteoprotegerin (OPG) is a secretory glycoprotein belonging to TNF receptor (TNFR) superfamily. As the name implies, it protects bone. Unlike other TNFRs it lacks a transmembrane domain and lacks any apparent cell associated signals. OPG consists of 401 amino acid with molecular mass of approximately 55 kD as a monomer and 110 kD as a disulfide-linked dimer. High levels of OPG mRNA has been detected in lung, heart, kidney, and placenta1. Recombinant OPG blocks osteoclastogenesis in vitro and increases bone density in vivo. Targeted deletion of OPG in mice results in severe early-onset of osteoporosity. These mice also exhibit increase in vascular calcification in the aorta and renal arteries suggesting that it may also play a role in degenerative arterial disease.
Synonyms OCIF; OPG; PDB5; TR1
Note This antibody is useful in Flow Cytometry: 0.2-1 ug/10^6 cells Immunocytochemistry/Immunofluorescence: see Sandra 2006 Immunohistochemistry (frozen): see Boumans 2012 for details. Immunoprecipitation: see Sandra 2006
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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