Cytochrome C (CYCS) Mouse Monoclonal Antibody [Clone ID: 7H8.2C12]

CAT#: TA336369

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Mouse Monoclonal Cytochrome c Antibody (7H8.2C12)



USD 465.00


Availability*
5 Days

Size
    • 100 ug


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Specifications

Product Data
Clone Name 7H8.2C12
Applications WB
Recommended Dilution WB: 0.05-0.5 ug/ml, FC: 1:10-1:1000, IF: 1:10-1:500, IHC: 1:10-1:500, IHC-P: 1:10-1:500
Reactivity Canine, Drosophila, Equine, Human, Mammalian, Mouse
Host Mouse
Isotype IgG2b, kappa
Clonality Monoclonal
Immunogen Synthetic peptides corresponding to amino acids 1-80, 81-104 and 66-104 of pigeon CYT were used as the immunogen (Jemmerson et al. 1991). The antibody recognizes an epitope within amino acids 93-104 of pigeon cytochrome C based on competitive ELISA result
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name cytochrome c, somatic
Background In addition to its well-known role in electron transport, cytochrome c (CYT) has been identified as a mediator of apoptosis or programmed cell death. Cytochrome c translocates from mitochondria into the cytoplasm in the early phases of apoptosis and plays a role in initiation of the apoptotic proteolytic cascade by activating caspase-3. Cytochrome c has been shown to bind Apaf-1. Apaf-1 has also been shown to activate capase-3.
Synonyms CYC; HCS; THC4
Note Useful in Flow Cytometry (Intracellular): See Mohr (2004) et al. Immunocytochemistry/Immunofluorescence: See Yamasaki (2006) et al. Immunohistochemistry-Paraffin: See Fujimara (1998). et al.
Reference Data
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Huntington's disease, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Small cell lung cancer, Viral myocarditis
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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