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FANCD2 Rabbit Polyclonal Antibody

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SKU
TA336272
Rabbit Polyclonal FANCD2 Antibody
Size:
50 ul
Conjugation:
Unconjugated
  $680.00
5 Days*
Bulk/Customize

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Specifications
Specifications
Product Data
Application ChIP, FC, ICC/IF, IHC, Immunoblotting, IP, Simple Western, WB
Recommended Dilution Immunocytochemistry/ Immunofluorescence: 5 ug/ml, Chromatin Immunoprecipitation (ChIP), Flow Cytometry: 2 - 5 ug/ml, Simple Western: 1:25, Immunoprecipitation: 1:10-1:500, Immunohistochemistry-Paraffin: 2.5-5.0 ug/ml, Immunohistochemistry: 2.5-5.0 ug/ml, Western Blot: 1 - 2 ug/ml, RNA Inhibition, Immunoblotting, Chromatin Immunoprecipitation, Knockdown Validated, Knockout Validated
Reactivity Human, Mouse, Primate
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Human FANCD2 fusion protein (N-terminal fragment). Swiss-Prot #Q9BXW9
Buffer Tris-glycine, 150mM NaCl, pH7.5, 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name Fanconi anemia complementation group D2
Database Link
Background Fanconi anemia (FANC) is a human autosomal-recessive cancer susceptibility disorder characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomycin C (MMC). The FANC subunit D2 protein is vital for cellular resistance to DNA cross-linking and the arrest of DNA synthesis after ionizing radiation (IR). DNA damage activates the monoubiquitination of FANCD2, targeting nuclear foci containing the BRCA1 protein.
Synonyms FA-D2; FA4; FACD; FAD; FAD2; FANCD
Note By Western blot, this antibody should recognize a band at ~166 kDa (post-translationally modified form). Additional bands may be seen at lower molecular weights. For immunofluorescence it has been tested in human MMC and IR treated MEF cells. This antibody may also be used for Immunoprecipitation and Immunohistochemistry-Paraffin
Reference Data
Protein Categories Cardiovascular diseases, Intracellular Proteins
Protein Families Druggable Genome
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.