PTCH1 Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-PTCH1 Antibody
Promo! Get it for USD 289.00, only with code 289*.
(*) Valid from April 1st to September 30th, 2020. See details »
|Recommended Dilution||WB, IHC|
|Immunogen||The immunogen for anti-PTCH1 antibody: synthetic peptide directed towards the C terminal of human PTCH1. Synthetic peptide located within the following region: TILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAM|
|Formulation||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Note that this product is shipped as lyophilized powder to China customers.
|Storage||Store at -20°C as received.|
|Stability||Stable for 12 months from date of receipt.|
|Predicted Protein Size||37 kDa|
|Gene Name||patched 1|
|Background||PTCH1 is a member of the patched gene family. The protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis. It functions as a tumor suppressor. Mutations of its gene have been associated with nevoid basal cell carcinoma syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly.|
|Synonyms||BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11|
|Note||Immunogen Sequence Homology: Dog: 100%; Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Guinea pig: 100%; Rabbit: 93%; Zebrafish: 79%|
|Protein Families||Druggable Genome, ES Cell Differentiation/IPS, Transmembrane|
|Protein Pathways||Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer|