Optineurin (OPTN) Rabbit Polyclonal Antibody

CAT#: TA332444

Rabbit anti-OPTN Polyclonal Antibody


 Product Datasheet for 'TA332444'

USD 335.00


Availability*
3 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB 1:500 - 1:2000, IHC 1:50- 1:200
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein of human OPTN
Isotype IgG
Formulation Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration 1 mg/ml
Purification Affinity purification
Predicted Protein Size 577
Gene Name optineurin
Background This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Synonyms ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP
Reference Data
Protein Families Druggable Genome
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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