Kcnab1 Rabbit Polyclonal Antibody

CAT#: TA328980

Rabbit polyclonal Anti-KVBeta1

Product Images

Western blot analysis of human SH-SY5Y neuroblastoma cell lysate (lanes 1 and 4), mouse brain lysate (lanes 2 and 5) and rat brain lysate (lanes 3 and 6): 1-3. Anti-KVβ1 antibody, (1:200). 4-6. Anti-KVβ1 antibody, preincubated with the control peptide antigen.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:200-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide (C)TPQHHISLKESTAK, corresponding to amino acid residues 54-67 of rat KVÃ?1. N-terminus.
• Formulation: Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
• Reconstitution Method: Add 50 ul double distilled water (DDW) to the lyophilized powder.
• Purification: Affinity purified on immobilized antigen.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: potassium voltage-gated channel subfamily A member regulatory beta subunit 1
• Database Link:
  NP_058999
  Entrez Gene 7881 HumanEntrez Gene 16497 MouseEntrez Gene 29737 Rat
  UniProt ID P63144
• Background: Voltage-gated K+ channels represent a structurally and functionally diverse group of membrane proteins. These channels establish the resting membrane potential and modulate the frequency and duration of action potentials in nerve and muscle1. The duration of the open states of K+ channels is determined by the rates of deactivation and inactivation. KV channels are hetero-oligomeric complexes consisting of two different types of subunits: membrane-bound, pore-forming a subunits and the smaller Ã? subunits. The Ã? subunits appear to be peripheral proteins tightly associated with the cytoplasmic side of the a subunits. The inactivation gate can be formed by an N-terminal segment of an auxiliary Ã?-subunit, as in the complex of KVÃ?1 and KVa family channels3. There are three mammalian KVÃ? genes: KVÃ?1, KVÃ?2 and KVÃ?3. Additional variability in the KVÃ?1 family results from alternative splicing in the amino terminal region, thus yielding the KVÃ?1.1, KVÃ?1.2, and KVÃ?1.3 subunits.
• Synonyms: AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1; Kvb1.3