KCNK1 Rabbit Polyclonal Antibody

CAT#: TA328620

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Rabbit Polyclonal Anti-K2P1.1 (TWIK-1) (extracellular)


Product Datasheet for 'TA328620'


USD 585.00


Availability*
3 Weeks

Size
    • 200 ul


Product images

Specifications

Product Data
Applications IHC, WB
Recommended Dilution WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Peptide RQELRKLKRRFLEEHEC, corresponding to amino acid residues 53-69 of human K2P1.1.Extracellular, near the P1 loop.
Formulation Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Purification Affinity purified on immobilized antigen.
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name potassium two pore domain channel subfamily K member 1
Background K2P1.1 (also named TWIK-1 or KCNK1) is a member of the 2-pore (2P) domain K+ channels family that at the moment includes 14 members. These channels show little time or voltage dependence and are considered to be â??leakâ? or â??backgroundâ? K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, etc. but are insensitive to the classical K+ channel blockers. K2P1.1 was the first of the K2P channels to be identified and as its original name indicates (Tandem of P domains in a Weak Inward rectifier K+ channel) the channel behaves as a weak inward rectifier when expressed in heterologous systems. The channel is ubiquitously expressed with the most prominent expression in the brain, kidney and heart. We have now produced a novel antibody directed against a highly conserved epitope in the extracellular region of the human K2P1.1 channel. The antibody will also react with rat and mouse samples.
Synonyms DPK; HOHO; K2P1; K2p1.1; KCNO1; TWIK-1; TWIK1
Reference Data
Protein Families Druggable Genome, Ion Channels: Potassium, Transmembrane
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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