MAP2 Rabbit Polyclonal Antibody

CAT#: TA327383

MAP2 Rabbit Polyclonal Antibody


 Product Datasheet for 'TA327383'

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USD 335.00


Availability*
3 Weeks

Size
    • 100 ug

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Specifications

Product Data
Applications WB, IHC
Recommend Dilution WB 1:500 - 1:2000;IHC 1:50 - 1:200
Reactivity H R
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein of human MAP2
Isotype IgG
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration 1mg/ml
Purification Affinity purification
Predicted Protein Size 59kDa
Gene Name microtubule associated protein 2
Background Microtubule-associated protein 2 (MAP2) is a neuronal phosphoprotein that regulates the structure and stability of microtubules, neuronal morphogenesis, cytoskeleton dynamics, and organelle trafficking in axons and dendrites. Multiple MAP2 isoforms are expressed in neurons, including high molecular weight MAP2A and MAP2B (280 and 270 kDa), and low molecular weight MAP2C and MAP2D (70 and 75 kDa). Phosphorylation of MAP2 modulates its association with the cytoskeleton and is developmentally regulated. GSK-3 and p44/42 MAP kinase phosphorylate MAP2 at Ser136, Thr1620, and Thr1623. Phosphorylation at Thr1620/1623 by GSK-3 inhibits MAP2 association with microtubules and microtubule stability.
Synonyms MAP2A|MAP2B|MAP2C
Reference Data
Protein Families ES Cell Differentiation/IPS, Adult stem cells, Druggable Genome
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.