Cullin 1(CUL1) Rabbit Polyclonal Antibody

CAT#: TA327291

CUL1 Rabbit Polyclonal Antibody

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 Product Datasheet for 'TA327291'

USD 335.00


Availability*
3 Weeks

Size
    • 100 ug

Product images

Specifications

Product Data
Applications WB, IHC, IF
Recommend Dilution WB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:10 - 1:100
Reactivity H M R
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein of human CUL1
Isotype IgG
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration 1mg/ml
Purification Affinity purification
Predicted Protein Size 90kDa
Gene Name cullin 1
Background Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the activation component E1; the activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein E2, then from E2 to ubiquitin ligase E3 for final delivery to the epsilon-NH2 of the target protein lysine residue. Combinatorial interactions of different E2 and E3 proteins result in substrate specificity. Recent data suggest that activated E2 associates transiently with E3, and that the dissociation is a critical step for ubiqitination. Cullin homolog 1 (CUL1), the mammalian homolog of Cdc53 from yeast, is a molecular scaffold of the SCF (Skp1/CUL1/F-box) E3 ubiquitin ligase protein complex. Thus, CUL1 and its family members function in ubiquitin dependent proteolysis. In particular, CUL1 has been shown to mediate ubiquitin dependent degradation of p21 Waf1/Cip1, cyclin D and IkappaB-alpha.
Synonyms -
Reference Data
Protein Families Druggable Genome
Protein Pathways Cell cycle, Oocyte meiosis, Ubiquitin mediated proteolysis, Wnt signaling pathway, TGF-beta signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.