CD51 (ITGAV) Rabbit Polyclonal Antibody

CAT#: TA327266

ITGAV Rabbit Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using ITGAV antibody.

Specifications

Product Data

• Applications: IHC, IP, WB
• Recommended Dilution: WB: 1:500-1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide of human ITGAV
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin subunit alpha V
• Database Link:
  NP_002201
  Entrez Gene 16410 MouseEntrez Gene 296456 RatEntrez Gene 3685 Human
  UniProt ID P06756
• Background: Integrins are a/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 a and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities . Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling).Several aV subfamily members, including aVβ3, aVβ5, aVβ1, are highly expressed in active endothelial cells and cancer cells where they play a critical role in angiogenesis and tumor metastasis. Therefore, interest has focused on aV integrin as a key therapeutic target in the treatment of cancer.
• Synonyms: CD51; MSK8; VNRA; VTNR

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Cell adhesion molecules (CAMs), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer