Glutathione Peroxidase 4 (GPX4) Rabbit Polyclonal Antibody
GPX4 Rabbit Polyclonal Antibody
Product Datasheet for 'TA327216'
|Applications||IF, IHC, WB|
|Recommend Dilution||WB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:10 - 1:100|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Recombinant protein of human GPX4|
|Formulation||Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3|
|Predicted Protein Size||22 kDa|
|Gene Name||glutathione peroxidase 4|
|Background||Glutathione peroxidase catalyzes the reduction of hydrogen peroxide, organic hydroperoxide, and lipid peroxides by reduced glutathione and functions in the protection of cells against oxidative damage. Human plasma glutathione peroxidase has been shown to be a selenium-containing enzyme and the UGA codon is translated into a selenocysteine. Through alternative splicing and transcription initiation, rat produces proteins that localize to the nucleus, mitochondrion, and cytoplasm. In humans, experimental evidence for alternative splicing exists; alternative transcription initiation and the cleavage sites of the mitochondrial and nuclear transit peptides need to be experimentally verified. [provided by RefSeq, Jul 2008]|
|Synonyms||GPx-4; GSHPx-4; MCSP; PHGPx; SMDS; snGPx; snPHGPx|
|Protein Families||Druggable Genome|
|Protein Pathways||Arachidonic acid metabolism, Glutathione metabolism|
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