IKB alpha (NFKBIA) Rabbit Polyclonal Antibody

CAT#: TA326981

NFKBIA Rabbit Polyclonal Antibody

Product Images

Western blot analysis of HL60 cell lysate using NFKBIA antibody.

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  Immunohistochemistry of paraffin-embedded human kidney using NFKBIA antibody at dilution of 1:200 (200x lens).

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  Immunohistochemistry of paraffin-embedded rat testis using NFKBIA antibody at dilution of 1:200 (400x lens).

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB 1:500 - 1:2000;IHC 1:50- 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human NFKBIA
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NFKB inhibitor alpha
• Database Link:
  NP_065390
  Entrez Gene 18035 MouseEntrez Gene 25493 RatEntrez Gene 4792 Human
  UniProt ID P25963
• Background: The NF-?B/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory I?B proteins. Activation occurs via phosphorylation of I?Ba at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-?B. I?Ba phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate I?B at these activating sites have been identified.
• Synonyms: IKBA; MAD-3; NFKBI

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway