MASPIN(SERPINB5) Rabbit Polyclonal Antibody
SERPINB5 Rabbit Polyclonal Antibody
Product Datasheet for 'TA326976'
|Recommend Dilution||WB: 1:500-1:2000; IHC: 1:50-1:200|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Recombinant protein of human SERPINB5|
|Formulation||Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3|
|Gene Name||serpin family B member 5|
|Background||Maspin (SERPINB5) was discovered as a mammary tumor suppressor that is expressed in normal mammary epithelium but lost in most breast cancer cell lines. While maspin is related to the serpin family of serine protease inhibitors, it may not function as a protease inhibitor. It plays an essential role in embryonic development through critical roles in cell adhesion. While the precise mechanism of maspin signaling is unclear, the tumor suppressing activity of maspin has been attributed to its ability to inhibit cell invasion/metastasis and angiogenesis, while promoting apoptosis. Nuclear translocation of active IKKa has been shown to repress maspin transcription and promote prostate cancer metastasis.|
|Protein Families||Secreted Protein, Druggable Genome|
|Protein Pathways||p53 signaling pathway|
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