NRG1 Rabbit Polyclonal Antibody

CAT#: TA326848

NRG1 Rabbit Polyclonal Antibody

 Product Datasheet for 'TA326848'

USD 335.00

3 Weeks

    • 100 ug

Product images


Product Data
Applications WB
Recommend Dilution WB: 1:500-1:2000; IHC: 1:50-1:200
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein of human NRG1
Isotype IgG
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration 1mg/ml
Purification Affinity purification
Gene Name neuregulin 1
Background Heregulin (HRG), also called neuregulin (NRG1), neu differentiation factor (NDF) or glial growth factor-2 (GGF-2), is a soluble growth factor synthesized as a transmembrane precursor molecule. Metalloproteinases and other proteases catalyze the cleavage of its extracellular domain which is then released and functions as a ligand for ErbB3 and ErbB4 receptor tyrosine kinase. The signaling pathways of HRG-ErbB3/ErbB4 are involved in regulation of cell proliferation, differentiation, invasion, and survival of both normal and malignant tissues. Abnormality of HRG-ErbB signaling leads to development of a variety of human diseases.HRG family has four isoforms including HRG-1, -2, -3 and -4, which are derived from alternative exon splicing. Moreover, they showed various tissue expression and biological activities.
Reference Data
Protein Families Secreted Protein, Transmembrane, Transcription Factors, Druggable Genome
Protein Pathways ErbB signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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