NRG1 Rabbit Polyclonal Antibody

CAT#: TA326848

NRG1 Rabbit Polyclonal Antibody


 Product Datasheet for 'TA326848'

USD 335.00


Availability*
3 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Applications WB
Recommend Dilution WB: 1:500-1:2000; IHC: 1:50-1:200
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein of human NRG1
Isotype IgG
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration 1mg/ml
Purification Affinity purification
Gene Name neuregulin 1
Background Heregulin (HRG), also called neuregulin (NRG1), neu differentiation factor (NDF) or glial growth factor-2 (GGF-2), is a soluble growth factor synthesized as a transmembrane precursor molecule. Metalloproteinases and other proteases catalyze the cleavage of its extracellular domain which is then released and functions as a ligand for ErbB3 and ErbB4 receptor tyrosine kinase. The signaling pathways of HRG-ErbB3/ErbB4 are involved in regulation of cell proliferation, differentiation, invasion, and survival of both normal and malignant tissues. Abnormality of HRG-ErbB signaling leads to development of a variety of human diseases.HRG family has four isoforms including HRG-1, -2, -3 and -4, which are derived from alternative exon splicing. Moreover, they showed various tissue expression and biological activities.
Synonyms ARIA|GGF|GGF2|HGL|HRG|HRG1|HRGA|MST131|MSTP131|NDF|NRG1-IT2|SMDF
Reference Data
Protein Families Secreted Protein, Transmembrane, Transcription Factors, Druggable Genome
Protein Pathways ErbB signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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