PSD95 (DLG4) Mouse Monoclonal Antibody [Clone ID: S28-43]

CAT#: TA326433

Mouse monoclonal PSD95 Antibody

Product Images

Immunolabelling of PSD95 using a dilution of the antibody

• 

  IF of PSD95 in cultures of dissociated hippocampal neurons. Cultures were grown and labeled with antibodies against the indicated proteins. A neuron double stained for PSD95.

Specifications

Product Data

• Clone Name: S28-43
• Applications: IF, IHC
• Recommended Dilution: WB: 1:1000
• Reactivities: Mouse, Rat, Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Fusion protein amino acids 77-200 of human PSD95/SAP90
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: discs large MAGUK scaffold protein 4
• Database Link:
  NP_001356
  Entrez Gene 13385 MouseEntrez Gene 29495 RatEntrez Gene 1742 Human
  UniProt ID P78352
• Background: Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex . These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds toneuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins . Thus different PDZ domains of PSD-95 might be specialized for distinct functions .PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) . The protein is implicated in experience dependent plasticity and plays an indispensable role in learning . Mutations in PSD95 are associated with autism .
• Synonyms: PSD95; SAP-90; SAP90
• Note: Detects ~95-110kDa.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Huntington's disease