Kallikrein 7 (KLK7) Rabbit Polyclonal Antibody

CAT#: TA324187

Anti-KLK7 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA324187 (KLK7 Antibody) at dilution 1/10 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA324187 (KLK7 Antibody) at dilution 1/10, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA324187 (KLK7 Antibody) at dilution 1/10 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA324187 (KLK7 Antibody) at dilution 1/10, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human colon cancer
  Predicted cell location: Cytoplasm, Nucleus
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 30-253 amino acids of human kallikrein-related peptidase 7
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: kallikrein related peptidase 7
• Database Link:
  NP_644806
  Entrez Gene 5650 Human
  UniProt ID P49862
• Background: This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation; the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis; and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene; which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19.
• Synonyms: hK7; PRSS6; SCCE

Reference Data

• Protein Families: Druggable Genome, Secreted Protein