CNTF Receptor alpha(CNTFR) Rabbit Polyclonal Antibody
Anti-CNTFR Rabbit Polyclonal Antibody
Product Datasheet for 'TA324163'
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|Recommend Dilution||ELISA: 1:1000-5000, WB: 1:500-2000, IHC: 1:25-100|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Fusion protein corresponding to a region derived from 23-342 amino acids of human ciliary neurotrophic factor receptor|
|Formulation||PBS pH7.3, 0.05% NaN3, 50% glycerol|
|Purification||Antigen affinity purification|
|Predicted Protein Size||41kDa|
|Gene Name||ciliary neurotrophic factor receptor|
|Background||This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor; which plays a critical role in neuronal cell survival; differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor; gp130 and leukemia inhibitory factor receptor; facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength; as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene.|
|Protein Families||Druggable Genome|
|Protein Pathways||Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway|