CHRM2 Rabbit Polyclonal Antibody

CAT#: TA323569

Anti-CHRM2 Rabbit Polyclonal Antibody

Product Images

Predicted cell location: Cytoplasm. Positive control: Human colon cancer tissue. Recommended dilution: 1/5-25 The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CHRM2 antibody at dilution 1/3, on the right is treated with the fusion protein. (Original magnification: x200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: ELISA: 1:1000-2000, IHC: 1:5-25
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 208-388 amino acids of human cholinergic receptor, muscarinic 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cholinergic receptor muscarinic 2
• Database Link:
  NP_000730
  Entrez Gene 81645 RatEntrez Gene 243764 MouseEntrez Gene 1129 Human
  UniProt ID P08172
• Background: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition; phosphoinositide degeneration; and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
• Synonyms: HM2

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton