smooth muscle Myosin heavy chain 11 (MYH11) Rabbit Polyclonal Antibody

CAT#: TA323338

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Anti-MYH11 Rabbit Polyclonal Antibody



USD 380.00


Availability*
2 Weeks

Size
    • 100 ul


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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 25-100
Positive control: Human cervical cancer
Predicted cell location: Cytoplasm, Nucleus
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 1958-1972 amino acids of Human myosin, heavy chain 11, smooth muscle
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name myosin, heavy chain 11, smooth muscle
Background The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein; converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene; and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed; with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms AAT4; FAA4; SMHC; SMMHC
Reference Data
Protein Pathways Tight junction, Vascular smooth muscle contraction, Viral myocarditis
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