HDAC2 Rabbit Polyclonal Antibody

CAT#: TA323157

Anti-HDAC2 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA323157 (HDAC2 Antibody) at dilution 1/17 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human breast cancer tissue using TA323157 (HDAC2 Antibody) at dilution 1/17, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA323157 (HDAC2 Antibody) at dilution 1/17 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA323157 (HDAC2 Antibody) at dilution 1/17, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 15-50
  Positive control: Human breast cancer
  Predicted cell location: Nucleus
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 474-488 amino acids of Human histone deacetylase 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: histone deacetylase 2
• Database Link:
  NP_001518
  Entrez Gene 15182 MouseEntrez Gene 3066 Human
  UniProt ID Q92769
• Background: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes; and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A; H2B; H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins; including YY1; a mammalian zinc-finger transcription factor. Thus; it plays an important role in transcriptional regulation; cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
• Synonyms: HD2; RPD3; YAF1

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency, Transcription Factors
• Protein Pathways: Cell cycle, Chronic myeloid leukemia, Huntington's disease, Notch signaling pathway, Pathways in cancer