Phospholipase C gamma 1 (PLCG1) Rabbit Polyclonal Antibody

CAT#: TA322973

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Anti-PLCG1 (phospho-Tyr771) Rabbit Polyclonal Antibody


Product Datasheet for 'TA322973'


USD 345.00


Availability*
4 Weeks

Size
    • 100 ul


Product images

Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1:500-1000, IF: 1:100-200
Reactivity Human, Mouse, Rat
Modifications Phospho-specific
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Peptide sequence around phosphorylation site of tyrosine 771 (P-D-Y(p)-G-A) derived from Human PLC-?1.
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration 1 mg/ml
Purification Antigen affinity purification
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 155 kDa
Gene Name phospholipase C gamma 1
Background The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1
Reference Data
Protein Families Druggable Genome
Protein Pathways Calcium signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Glioma, Inositol phosphate metabolism, Leukocyte transendothelial migration, Metabolic pathways, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Phosphatidylinositol signaling system, T cell receptor signaling pathway, VEGF signaling pathway, Vibrio cholerae infection
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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