AMPK beta 1 (PRKAB1) Rabbit Polyclonal Antibody

CAT#: TA322521

Anti-PRKAB1 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human stomach cancer tissue using TA322521 (PRKAB1 Antibody) at dilution 1/15 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human stomach cancer tissue using TA322521 (PRKAB1 Antibody) at dilution 1/15, treated with synthetic peptide. (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322521 (PRKAB1 Antibody) at dilution 1/15 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322521 (PRKAB1 Antibody) at dilution 1/15, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 10-50
  Positive control: Human stomach cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 1-14 amino acids of Human protein kinase, AMP-activated, beta 1 non-catalytic subunit
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: protein kinase AMP-activated non-catalytic subunit beta 1
• Database Link:
  NP_006244
  Entrez Gene 19079 MouseEntrez Gene 83803 RatEntrez Gene 5564 Human
  UniProt ID Q9Y478
• Background: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit; and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses; AMPK is activated; and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR); key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
• Synonyms: AMPK; HAMPKb

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Adipocytokine signaling pathway, Hypertrophic cardiomyopathy (HCM), Insulin signaling pathway