PDCD10 Rabbit Polyclonal Antibody
Anti-PDCD10 Rabbit Polyclonal Antibody
Product Datasheet for 'TA322434'
|Recommend Dilution||ELISA: 1:1000-5000, WB: 1:200-1000, IHC: 1:25-100|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Full length fusion protein|
|Formulation||PBS pH7.3, 0.05% NaN3, 50% glycerol|
|Purification||Antigen affinity purification|
|Predicted Protein Size||25kDa|
|Gene Name||programmed cell death 10|
|Background||This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25; and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations; which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants; encoding the same protein; have been identified.|
|Protein Families||Druggable Genome|
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