Calpain 6 (CAPN6) Rabbit Polyclonal Antibody

CAT#: TA322386

Anti-CAPN6 Rabbit Polyclonal Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane 1-2: TM4 and NIH/3T3 cell lysates Primary antibody: TA322386 (CAPN6 Antibody) at dilution 1/500 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 15 seconds

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322386 (CAPN6 Antibody) at dilution 1/70 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA322386 (CAPN6 Antibody) at dilution 1/70, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: TM4 and NIH/3T3 cell lysates
  IHC: 50-100
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 26-343 amino acids of human calpain 6
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: calpain 6
• Database Link:
  NP_055104
  Entrez Gene 12338 MouseEntrez Gene 83685 RatEntrez Gene 827 Human
  UniProt ID Q9Y6Q1
• Background: Calpains are ubiquitous; well-conserved family of calcium-dependent; cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain; and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes; as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.
• Synonyms: CalpM; CANPX; CAPNX; DJ914P14.1

Reference Data

• Protein Families: Druggable Genome, Protease