MCSF Receptor (CSF1R) Rabbit Polyclonal Antibody

CAT#: TA321691

Anti-CSF1R Rabbit Polyclonal Antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane: 231 cells Primary antibody: TA321691 (CSF1R Antibody) at dilution 1/800 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 2 seconds

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 500-2000
  WB positive control: 231 cells
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 955-972 amino acids of Human colony stimulating factor 1 receptor
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 108 kDa
• Gene Name: colony stimulating factor 1 receptor
• Database Link:
  NP_005202
  Entrez Gene 12978 MouseEntrez Gene 307403 RatEntrez Gene 1436 Human
  UniProt ID P07333
• Background: The protein encoded by this gene is the receptor for colony stimulating factor 1; a cytokine which controls the production; differentiation; and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
• Synonyms: C-FMS; CD115; CSF-1R; CSFR; FIM2; FMS; HDLS; M-CSF-R

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Pathways in cancer