Aconitase 1 (ACO1) Rabbit Polyclonal Antibody

CAT#: TA321448

Anti-ACO1 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA321448 (ACO1 Antibody) at dilution 1/50 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA321448 (ACO1 Antibody) at dilution 1/50, treated with synthetic peptide. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA321448 (ACO1 Antibody) at dilution 1/50 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human lung cancer tissue using TA321448 (ACO1 Antibody) at dilution 1/50, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 132-146 amino acids of human aconitase 1, soluble
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: aconitase 1
• Database Link:
  NP_002188
  Entrez Gene 11428 MouseEntrez Gene 50655 RatEntrez Gene 48 Human
  UniProt ID P21399
• Background: Aconitase 1; also known as iron regulatory element binding protein 1 (IREB1); is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA; and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA; and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus; IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity; and hence grouped with the aconitase family of enzymes.
• Synonyms: ACONS; HEL60; IREB1; IREBP; IREBP1; IRP1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Citrate cycle (TCA cycle), Glyoxylate and dicarboxylate metabolism, Metabolic pathways