Frizzled 2 (FZD2) Rabbit Polyclonal Antibody

CAT#: TA321353

Anti-FZD2 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human renal cancer tissue using TA321353 (FZD2 Antibody) at dilution 1/25 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human renal cancer tissue using TA321353 (FZD2 Antibody) at dilution 1/25, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human renal cancer
  Predicted cell location: Cytoplasm, Cell membrane
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 188-190 amino acids of human led family receptor 2
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: frizzled class receptor 2
• Database Link:
  NP_001457
  Entrez Gene 57265 MouseEntrez Gene 64512 RatEntrez Gene 2535 Human
  UniProt ID Q14332
• Background: This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family; member 3A and wingless-type MMTV integration site family; member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.
• Synonyms: fz-2; Fz2; fzE2; hFz2

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway