HLAE(HLA-E) Mouse Monoclonal Antibody [Clone ID: 3D12HLA-E]

CAT#: TA320346

Mouse Anti-Human HLA-E Purified (25 ug)

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 Product Datasheet for 'TA320346'

USD 185


Availability*
2 Weeks

Size
    • 25 ug

Product images

Specifications

Product Data
Clone Name 3D12HLA-E
Applications FC
Recommend Dilution Flow, IP, WB
Reactivity Human
Host Mouse
Clonality Monoclonal
Formulation Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5-1mg/ml (lot dependent)
Purification Affinity purified
Gene Name major histocompatibility complex, class I, E
Background The monoclonal antibody 3D12 (HLA-E) recognizes human HLA-E, a member of the Human Leukocyte Antigen family. HLA-E is a MHC Class IB member, which has a specialized role in NK cell recognition. Binding of a restricted set of peptides derived from other Class I leader sequences to the HLA-E and B2M (beta2 microglobulin) complex leads to interaction with NKG2A on NK cells. This binding protects the HLA-G-expressing cell from NK cell killing. HLA-E expression is ubiquitous.
Synonyms EA1.2|EA2.1|HLA-6.2|MHC|QA1
Reference Data
Protein Families Transmembrane
Protein Pathways Endocytosis, Cell adhesion molecules (CAMs), Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Viral myocarditis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.