VEGF Receptor 1 (FLT1) Rat Monoclonal Antibody [Clone ID: 7A6]

CAT#: TA320332

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Rat Anti-Human VEGF Receptor 1 (Flt1) Purified (25 ug)


 Product Datasheet for 'TA320332'

USD 170.00


Availability*
5 Days

Size
    • 25 ug


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Specifications

Product Data
Clone Name 7A6
Applications WB
Recommend Dilution WB
Reactivity Human
Host Rat
Clonality Monoclonal
Formulation Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5-1mg/ml (lot dependent)
Purification Affinity purified
Gene Name fms related tyrosine kinase 1
Background This 7A6 monoclonal antibody recognizes human VEGFR1 (vascular endothelial growth factor receptor 1, fms-like tyrosine kinase 1, FLT1). It is directed against the extracellular domain and can recognize both membrane-bound and soluble forms of VEGFR1, with approximate molecular weights of 180 kDa and 90 kDa, respectively. Mice lacking expression of VEGFR1 have disorganized vasculature and die in utero, however angiogenesis does not require the tyrosine kinase activity of VEGFR1 as expression of a membrane-bound form lacking the tyrosine kinase domain allows normal development. Although fertile and viable, mice lacking the tyrosine kinase domain of VEGFR1 do have a defect in the migration of macrophages. The soluble form of VEGFR1 can be detected in the serum of normal patients, and elevated levels of soluble VEGFR1 in pregnant women is associated with preeclampsia. Several tumor cell lines have been reported to express membrane-bound VEGFR1, including malignancies of hematopoietic origin.
Synonyms FLT; FLT-1; VEGFR-1; VEGFR1
Reference Data
Protein Families Druggable Genome, Protein Kinase, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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