TMEM59L Rabbit Polyclonal Antibody

CAT#: TA319872

Rabbit Polyclonal TMEM59L Antibody

Product Images

Western blot analysis of TMEM59L in rat heart tissue lysate with TMEM59L antibody at 1 ug/mL.

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  Immunohistochemistry of TMEM59L in mouse brain tissue with TMEM59L antibody at 2.5 ug/mL.

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  Immunofluorescence of TMEM59L in mouse brain tissue with TMEM59L antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TMEM59L antibody was raised against a 19 amino acid synthetic peptide near carboxy terminus of human TMEM59L.
• Formulation: TMEM59L Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: TMEM59L Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: transmembrane protein 59 like
• Database Link:
  NP_036241
  Entrez Gene 67937 MouseEntrez Gene 306349 RatEntrez Gene 25789 Human
  UniProt ID Q9UK28
• Background: TMEM59L Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.
• Synonyms: BSMAP; C19orf4

Reference Data

• Protein Families: Transmembrane