Snf1lk2 (SIK2) Rabbit Polyclonal Antibody

CAT#: TA319849

Rabbit Polyclonal SIK2 Antibody

Product Images

Western blot analysis of SIK2 in SW480 cell lysate with SIK2 antibody at 1 ug/mL.

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  Immunocytochemistry of SIK2 in SW480 cells with SIK2 antibody at 2.5 ug/mL.

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  Immunofluorescence of SIK2 in SW480 cells with SIK2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SIK2 antibody was raised against a 16 amino acid synthetic peptide near the center of human SIK2.
• Formulation: SIK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SIK2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: salt inducible kinase 2
• Database Link:
  NP_056006
  Entrez Gene 235344 MouseEntrez Gene 315649 RatEntrez Gene 23235 Human
  UniProt ID Q9H0K1
• Background: SIK2 Antibody: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
• Synonyms: LOH11CR1I; QIK; SIK-2; SNF1LK2

Reference Data

• Protein Families: Druggable Genome, Protein Kinase