Snf1lk2 (SIK2) Rabbit Polyclonal Antibody

CAT#: TA319849

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Rabbit Polyclonal SIK2 Antibody



USD 528.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen SIK2 antibody was raised against a 16 amino acid synthetic peptide near the center of human SIK2.
Formulation SIK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification SIK2 Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name salt inducible kinase 2
Background SIK2 Antibody: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
Synonyms LOH11CR1I; QIK; SIK-2; SNF1LK2
Reference Data
Protein Families Druggable Genome, Protein Kinase
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.