N4BP1 Rabbit Polyclonal Antibody

CAT#: TA319783

Rabbit Polyclonal N4BP1 Antibody

Product Images

Western blot analysis of N4BP1 in HeLa cell lysate with N4BP1 antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunofluorescence of N4BP1 in HeLa cells with N4BP1 antibody at 20 ug/mL.

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  Immunocytochemistry of N4BP1 in HeLa cells with N4BP1 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 0.5 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: N4BP1 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human N4BP1.
• Formulation: N4BP1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: N4BP1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NEDD4 binding protein 1
• Database Link:
  NP_694574
  Entrez Gene 80750 MouseEntrez Gene 291921 RatEntrez Gene 9683 Human
  UniProt ID O75113
• Background: N4BP1 Antibody: Nedd4-binding partner-1 (N4BP1) is a developmentally expressed protein interactor and monoubiquitylation substrate of Nedd4, a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins and may have a fundamental role to play in embryonic processes. N4BP1 can undergo Nedd4-mediated polyubiquitylation and proteosomal degradation. N4BP1 also functions as a negative regulator of AIF4 (also known as ITCH or Atrophin-1), an E3-ubiquitin ligase, by interacting with the second WW domain of AIF4 and impairing ubiquitination of substrates.
• Synonyms: FLJ31821; KIAA0615; MGC176730