RANKL (TNFSF11) Rabbit Polyclonal Antibody

CAT#: TA308970

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Rabbit Polyclonal antibody to RANKL (tumor necrosis factor (ligand) superfamily, member 11)


Product Datasheet for 'TA308970'


USD 415.00


Availability*
In Stock

Size
    • 100 ul


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Specifications

Product Data
Applications IHC, WB
Recommend Dilution IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity Human (Predicted: Bovine, Chicken, Mouse)
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region within amino acids 253 and 317 of RANKL (Uniprot ID#O14788)
Formulation 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration 1 mg/ml
Purification Purified by antigen-affinity chromatography.
Predicted Protein Size 35 kDa
Gene Name tumor necrosis factor superfamily member 11
Background This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq]
Synonyms CD254; ODF; OPGL; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2; sOdf
Note Seq homology of immunogen across species: Mouse (93%), Chicken (87%), Bovine (100%)
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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