BLNK Rabbit Polyclonal Antibody

CAT#: TA308826

Rabbit polyclonal antibody to B-cell linker protein (B-cell linker)

Product Images

Sample (30 ug of whole cell lysate). A: Hela. 10% SDS PAGE. TA308826 diluted at 1:500.

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using B-cell linker protein (TA308826) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human (Predicted: Mouse, Rat, Bovine)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 394 and 456 of BLNK (Uniprot ID#Q8WV28)
• Formulation: 1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 50 kDa
• Gene Name: B-cell linker
• Database Link:
  NP_001107566
  Entrez Gene 17060 MouseEntrez Gene 499356 RatEntrez Gene 29760 Human
  UniProt ID Q8WV28
• Background: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
• Synonyms: AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65
• Note: Seq homology of immunogen across species: Mouse (100%), Rat (100%), Bovine (100%)

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: B cell receptor signaling pathway, Primary immunodeficiency