ERCC8 Rabbit Polyclonal Antibody

CAT#: TA308521

Rabbit Polyclonal antibody to CSA (excision repair cross-complementing rodent repair deficiency, complementation group 8)

Product Images

ERCC8 antibody detects ERCC8 protein by Western blot analysis. A. 30 ug C8D30 whole cell lysate/extract. 10 % SDS-PAGE. ERCC8 antibody (TA308521) dilution: 1:1000

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  ERCC8 antibody detects ERCC8 protein by Western blot analysis. A. 30 ug Rat2 whole cell lysate/extract. 10 % SDS-PAGE. ERCC8 antibody (TA308521) dilution: 1:1000

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  Sample (30ug whole cell lysate). A:MOLT4. 10% SDS PAGE. TA308521 diluted at 1:1000

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using ERCC8 (TA308521) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 194 of CSA (Uniprot ID#Q13216)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Affinity purified by Protein A.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 44 kDa
• Gene Name: ERCC excision repair 8, CSA ubiquitin ligase complex subunit
• Database Link:
  NP_001007234
  Entrez Gene 71991 MouseEntrez Gene 1161 Human
  UniProt ID Q13216
• Background: This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. [provided by RefSeq]
• Synonyms: CKN1; CSA; UVSS2

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Nucleotide excision repair, Ubiquitin mediated proteolysis