Protein kinase like protein SgK493(Pkdcc) Rabbit Polyclonal Antibody

CAT#: TA306903

Rabbit Polyclonal VLK Antibody

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 Product Datasheet for 'TA306903'

USD 371


Availability*
In Stock

Size
    • 100 ug

Product images

Specifications

Product Data
Applications WB, IHC, IF
Recommend Dilution WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 5 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen VLK antibody was raised against a 15 amino acid peptide from near the center of human VLK.
Isotype IgG
Formulation PBS containing 0.02% sodium azide.
Concentration 1mg/ml
Purification Affinity chromatography purified via peptide column
Gene Name protein kinase domain containing, cytoplasmic
Background VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not belong to any known protein kinase groups. VLK is initially expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, but its expression is later confined to E-cadherin-negative mesenchyme. It is enriched in the Golgi apparatus and is thought to regulate the rate of protein export from the Golgi. Targeted disruption of VLK in mice leads to a defect in lung development and neonatal lethality. It has been suggested that mutations in VLK may be associated with the allergic condition atopy.
Synonyms SGK493|Vlk
Reference Data
Protein Families Protein Kinase, Druggable Genome
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Citations