MRE11 Rabbit Polyclonal Antibody

CAT#: TA306897

Rabbit Polyclonal MRE11 Antibody

Product Images

Western blot analysis of MRE11 in rat lung tissue lysate with MRE11 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of MRE11 in rat lung tissue with MRE11 antibody at 5 ug/mL.

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  Immunofluorescence of MRE11 in rat lung tissue with MRE11 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: MRE11 antibody was raised against a 14 amino acid peptide from near the amino terminus human MRE11.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: MRE11 homolog A, double strand break repair nuclease
• Database Link:
  NP_005581
  Entrez Gene 17535 MouseEntrez Gene 64046 RatEntrez Gene 4361 Human
  UniProt ID P49959
• Background: MRE11 is involved in the repair of DNA double strand breaks as part of a complex that includes the Rad50 and NBS1 protein and is thought to act in the same pathway as the A-T mutated (ATM) protein. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for non-homologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Mutations in this protein result in a novel ataxia telangiectasia-like disorder (ATLD). Unlike the ATM protein, MRE11 is necessary proper mammalian development.
• Synonyms: ATLD; HNGS1; MRE11; MRE11B

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency
• Protein Pathways: Homologous recombination, Non-homologous end-joining