Activin Receptor Type IA(ACVR1) Rabbit Polyclonal Antibody

CAT#: TA306640

Rabbit Polyclonal ACVR1 Antibody

Antibody Service

 Product Datasheet for 'TA306640'

USD 371.00

5 Days

    • 100 ug

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Product Data
Applications WB
Recommend Dilution WB: 1 ug/mL
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen ACVR1 antibody was raised against a 14 amino acid peptide near the amino terminus of the human ACVR1.
Isotype IgG
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Gene Name activin A receptor type 1
Background Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. Unlike ACVR1B and ACVR1C, ACVR1, also known as activin receptor-like kinase 2 (ALK2), can not transduce activin-mediated signaling, but will transduce BMP and Mullerian inhibiting substance (MIS) group signaling. It is thought that ACVR1 also inhibits activin signaling by blocking the binding of activin to its type II receptor. Recent studies indicate that genetic variation in ACVR1 is associated with polycystic ovary syndrome, suggesting that ACVR1 signaling contributes to disturbed folliculogenesis in these patients. At least four isoforms of ACVR1 are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1B or ACVR1C.
Reference Data
Protein Families Protein Kinase, ES Cell Differentiation/IPS, Transmembrane, Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
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