LIMPII (SCARB2) Rabbit Polyclonal Antibody

CAT#: TA306597

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Rabbit Polyclonal LIMP2 Antibody


 Product Datasheet for 'TA306597'

USD 415.00


Availability*
5 Days

Size
    • 100 ug


Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 1 - 2 ug/mL, ICC: 10 ug/mL
Reactivity Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen LIMP2 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human LIMP2.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Gene Name scavenger receptor class B member 2
Background The lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind b-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted b-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor. Despite its predicted molecular weight, LIMP2 runs at approximately 80 – 85 kDa in SDS-PAGE.
Synonyms AMRF; CD36L2; EPM4; HLGP85; LGP85; LIMP-2; LIMPII; SR-BII
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Lysosome
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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68 Mouse Clones