LIMPII (SCARB2) Rabbit Polyclonal Antibody

CAT#: TA306583

Rabbit Polyclonal LIMP2 Antibody

Product Images

Western blot analysis of LIMP2 in human skeletal muscle tissue lysate with LIMP2 antibody at 1 ug/ml in (A) the absence and (B) presence of blocking peptide.

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  Immunohistochemistry of LIMP2 in human skeletal muscle with LIMP2 antibody at 2.5 ug/ml.

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  Immunofluorescence of LIMP2 in Human Skeletal Muscle tissue with LIMP2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LIMP2 antibody was raised against a 16 amino acid peptide from near the center of human LIMP2.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: scavenger receptor class B member 2
• Database Link:
  AAH21892
  Entrez Gene 950 Human
  UniProt ID Q14108
• Background: The lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind b-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted b-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor. Despite its predicted molecular weight, LIMP2 runs at approximately 80 – 85 kDa in SDS-PAGE.
• Synonyms: AMRF; CD36L2; EPM4; HLGP85; LGP85; LIMP-2; LIMPII; SR-BII