PD1(PDCD1) Rabbit Polyclonal Antibody

CAT#: TA306404

Rabbit Polyclonal PD-1 Antibody


 Product Datasheet for 'TA306404'

USD 415.00


Availability*
5 Days

Size
    • 100 ug


Product images

Specifications

Product Data
Applications WB, IHC
Recommend Dilution WB: 1 ug/mL, ICC: 5 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen PD-1 antibody was raised against a 16 amino acid peptide from near the center of human PD-1.
Isotype IgG
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Gene Name programmed cell death 1
Background Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of “danger signals” such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Synonyms CD279|PD-1|PD1|SLEB2|hPD-1|hPD-l|hSLE1
Reference Data
Protein Families Transmembrane, Druggable Genome
Protein Pathways Cell adhesion molecules (CAMs), T cell receptor signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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