PD1(PDCD1) Rabbit Polyclonal Antibody
Rabbit Polyclonal PD-1 Antibody
Product Datasheet for 'TA306404'
|Recommend Dilution||WB: 1 ug/mL, ICC: 5 ug/mL|
|Reactivity||Human, Mouse, Rat|
|Immunogen||PD-1 antibody was raised against a 16 amino acid peptide from near the center of human PD-1.|
|Formulation||PBS containing 0.02% sodium azide.|
|Purification||Affinity chromatography purified via peptide column|
|Gene Name||programmed cell death 1|
|Background||Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of “danger signals” such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.|
|Protein Families||Transmembrane, Druggable Genome|
|Protein Pathways||Cell adhesion molecules (CAMs), T cell receptor signaling pathway|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.