RANKL (TNFSF11) Rabbit Polyclonal Antibody
Rabbit Polyclonal sRANK Ligand Antibody
Product Datasheet for 'TA306362'
|Recommend Dilution||WB: 0.25 - 0.5 ug/mL, ICC: 5 ug/mL|
|Reactivity||Human, Mouse, Rat|
|Immunogen||sRANK-L antibody was raised against a 14 amino acid peptide from near the center of human sRANK-L .|
|Formulation||PBS containing 0.02% sodium azide.|
|Purification||Affinity chromatography purified via peptide column|
|Gene Name||tumor necrosis factor superfamily member 11|
|Background||The receptor activator of NF-kappaB ligand (RANK-L) is a recently discovered member of the TNF-ligand family involved in the regulation of the T cell-dependent immune response, lymph node organogenesis and bone formation. RANK-L exists as both a normal, transmembrane form and a truncated, soluble form (sRANK-L), both of which can stimulate the receptor. Activation of T cells, such as by treatment with interleukin-7, induces RANK-L production and leads to an increase of osteoclast formation and bone loss. Finally, sRANK-L can activate the antiapoptotic kinase Akt through a signaling complex involving Src kinase and TRAF6, suggesting sRANK-L may also play a role in regulating apoptosis. This antibody will recognize both the soluble form and the uncleaved transmembrane form of RANK-L.|
|Synonyms||CD254; ODF; OPGL; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2; sOdf|
|Protein Families||Druggable Genome, Transmembrane|
|Protein Pathways||Cytokine-cytokine receptor interaction|
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