BCL2 Rabbit Polyclonal Antibody

CAT#: TA306171

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Rabbit Polyclonal Bcl-2 Antibody



USD 484.00


Availability*
2 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1 - 4 ug/mL, IHC: 2 ug/mL, IF: 10 ug/mL
Reactivity Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Bcl-2 antibody was raised against a peptide corresponding to 15 amino acids near the N-terminus of human Bcl-2.
Formulation PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification Ion exchange chromatography purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name B-cell CLL/lymphoma 2
Background Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis (reviewed in 2 and 3). These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis (4). It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad (5 for review). Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer (4,6).
Synonyms Bcl-2; PPP1R50
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane
Protein Pathways Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Focal adhesion, Neurotrophin signaling pathway, Pathways in cancer, Prostate cancer, Small cell lung cancer
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