CARD15 (NOD2) Rabbit Polyclonal Antibody

CAT#: TA306091

Reviews ()
Write a review

Rabbit Polyclonal NOD2 Antibody


 Product Datasheet for 'TA306091'

USD 415.00


Availability*
5 Days

Size
    • 100 ug


Product images

Specifications

Product Data
Applications IF, WB
Recommend Dilution WB: 1 - 4 ug/mL, ICC: 5 ug/mL, IF: 10 ug/mL
Reactivity Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen NOD2 antibody was raised against a synthetic peptide corresponding to 16 amino acids at the amino terminus of human NOD2. The immunogen is located within the first 50 amino acids of NOD2.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Immunoaffinity chromatography purified IgG
Gene Name nucleotide binding oligomerization domain containing 2
Background Apaf-1 and NOD1 are members of a new family (1), which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2 (2). NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-kappaB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn’s disease (3,4) that is a main type of chronic inflammatory bowel disease.
Synonyms ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1
Reference Data
Protein Families Druggable Genome
Protein Pathways NOD-like receptor signaling pathway
Other products for "NOD2"
Frequently bought together (2)
Transient overexpression lysate of nucleotide-binding oligomerization domain containing 2 (NOD2)
    • 100 ug

USD 495.00


beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 150.00

Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Antibody Performance Guarantee banner
ANTIBODY VALIDATION 101
BOGO Free lysates
68 Mouse Clones