CARD15 (NOD2) Rabbit Polyclonal Antibody
Rabbit Polyclonal NOD2 Antibody
Product Datasheet for 'TA306091'
|Recommend Dilution||WB: 1 - 4 ug/mL, ICC: 5 ug/mL, IF: 10 ug/mL|
|Immunogen||NOD2 antibody was raised against a synthetic peptide corresponding to 16 amino acids at the amino terminus of human NOD2. The immunogen is located within the first 50 amino acids of NOD2.|
|Formulation||PBS containing 0.02% sodium azide.|
|Purification||Immunoaffinity chromatography purified IgG|
|Gene Name||nucleotide binding oligomerization domain containing 2|
|Background||Apaf-1 and NOD1 are members of a new family (1), which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2 (2). NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-kappaB, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn’s disease (3,4) that is a main type of chronic inflammatory bowel disease.|
|Synonyms||ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1|
|Protein Families||Druggable Genome|
|Protein Pathways||NOD-like receptor signaling pathway|
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