BCMA (TNFRSF17) Rabbit Polyclonal Antibody

CAT#: TA306065

Rabbit Polyclonal BCMA Antibody

Product Images

Western blot analysis of BCMA in human spleen (A) tissue lysate, K562 (B), and U937 (C) cell lysates with BCMA antibody at 5 ug/ml.

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  Immunohistochemistry of BCMA in human spleen cells with BCMA antibody at 10 ug/ml.

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  Immunofluorescence of BCMA in Human Spleen tissue with BCMA antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 5 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: BCMA antibody was raised against a synthetic peptide mapping at the carboxy terminus of human BCMA .
• Formulation: PBS containing 0.02% sodium azide.
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor receptor superfamily member 17
• Database Link:
  NP_001183
  Entrez Gene 608 Human
  UniProt ID Q02223
• Background: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 (1-4) and April/TALL-2, respectively, (3,5). BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion (1,2). April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified (6,7). BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
• Synonyms: BCM; BCMA; CD269; TNFRSF13A

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction