RAF1 Rabbit Monoclonal Antibody [Clone ID: Y198]

CAT#: TA303679

Rabbit monoclonal antibody against Raf-1(Y198)

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 Product Datasheet for 'TA303679'

USD 516.00


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Size
    • 100 ul

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Specifications

Product Data
Clone Name Y198
Applications WB, IHC
Recommend Dilution WB: 1:500; IHC: 1:50-100; ICC: 1:50; IP: 1:100
Reactivity Mouse, Rat, Human
Host Rabbit
Clonality Monoclonal
Immunogen A synthetic peptide corresponding to residues surrounding Serine 338-339 of human Raf was used as immunogen.
Isotype IgG
Formulation PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Reconstitution Method Reconstitute with PBS (pH7.3). To use this carrier-free antibody for conjugation experiment, we strongly recommend you to perform another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Protein A purified
Predicted Protein Size 73 kDa
Gene Name Raf-1 proto-oncogene, serine/threonine kinase
Background This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq].
Synonyms CMD1NN|CRAF|NS5|Raf-1|c-Raf
Reference Data
Protein Families Protein Kinase, Druggable Genome
Protein Pathways MAPK signaling pathway, ErbB signaling pathway, Chemokine signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Focal adhesion, Gap junction, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Melanogenesis, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Chronic myeloid leukemia, Acute myeloid leukemia, Non-small cell lung cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations