CNTFR Goat Polyclonal Antibody
Goat Polyclonal Antibody against CNTFR
Product Datasheet for 'TA303173'
|Recommend Dilution||ELISA: 1:16,000. WB: 0.3-1µg/ml.|
|Reactivity||Test: Mouse. Expected from seq similarity: Human, Mouse, Rat, Dog|
|Immunogen||Peptide with sequence CRSNTYPKGFY, from the internal region of the protein sequence according to NP_671693.1; NP_001833.1.|
|Formulation||Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purification||Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.|
|Gene Name||Mus musculus ciliary neurotrophic factor receptor (Cntfr), transcript variant 1|
|Background||This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq].|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.