ErbB 3(ERBB3) Goat Polyclonal Antibody

CAT#: TA303054

Goat Polyclonal Antibody against ERBB3

Antibody Service


 Product Datasheet for 'TA303054'

USD 360


Availability*
2 Weeks

Size
    • 100 ug

Product images

Specifications

Product Data
Applications WB, IHC
Recommend Dilution ELISA: 1:32,000. WB: 0.1-0.3µg/ml.IHC:5µg/ml.
Reactivity Test: Human. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig, Cow
Host Goat
Clonality Polyclonal
Immunogen Peptide with sequence C-HSRLFPKANAQRT, from the C Terminus of the protein sequence according to NP_001973.2.
Isotype Goat IgG
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration 0.5 mg/ml
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Gene Name erb-b2 receptor tyrosine kinase 3
Background This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq].
Synonyms ErbB-3|HER3|LCCS2|MDA-BF-1|c-erbB-3|c-erbB3|erbB3-S|p180-ErbB3|p45-sErbB3|p85-sErbB3
Reference Data
Protein Families Protein Kinase, Secreted Protein, Transmembrane, Stem cell - Pluripotency, Adult stem cells, Druggable Genome
Protein Pathways ErbB signaling pathway, Calcium signaling pathway, Endocytosis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.