GUCY1A1 Rabbit Polyclonal Antibody

CAT#: TA302112

Rabbit Polyclonal Antibody against GUCY1A3 (N-term)

Product Images

Western blot analysis of GUCY1A3 (arrow) using GUCY1A3 Antibody (N-term) (Cat.#TA302112). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the GUCY1A3 gene (Lane 2) (Origene Technologies).

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  Western blot analysis of anti-GUCY1A3 Pab (Cat. #TA302112) in mouse brain tissue lysate (35ug/lane). GUCY1A3 (arrow) was detected using the purified Pab.

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  Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000, IHC: 1:10~50
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This Guanylyl Cyclase alpha 1 (GUCY1A3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-300 amino acids from the N-terminal region of human Guanylyl Cyclase alpha 1 (GUCY1A3).
• Formulation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 77452 Da
• Gene Name: guanylate cyclase 1, soluble, alpha 3
• Database Link:
  NP_000847
  Entrez Gene 2982 Human
  UniProt ID Q02108
• Background: Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
• Synonyms: GC-SA3; GUC1A3; GUCA3; GUCSA3; GUCY1A1; MYMY6

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Gap junction, Long-term depression, Purine metabolism, Vascular smooth muscle contraction