HSP27(HSPB1) Rabbit Polyclonal Antibody

CAT#: TA302047

Rabbit Polyclonal Antibody against HSPB1 (S78)

Antibody Service


 Product Datasheet for 'TA302047'

USD 410


Availability*
2 Weeks

Size
    • 100 ug

Product images

Specifications

Product Data
Applications WB, IHC
Recommend Dilution WB: 1:1000, IHC: 1:10~50
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen This HSP27(HSPB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from human HSP27(HSPB1).
Isotype Rabbit Ig
Formulation Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Concentration 0.25 mg/ml
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Predicted Protein Size 22783 Da
Gene Name heat shock protein family B (small) member 1
Background In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSBP1 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoters (e.g. phorbol esters) and calcium ionophores, and high levels are associated with carcinoma of the breast and with endometrial adenocarcinomas. Heat shock of HeLa cell cultures, or treatment with arsenite, phorbol ester, or tumor necrosis factor, causes a rapid phosphorylation of preexisting HSBP1, with Ser82 as the major site and Ser78 the minor site of phosphorylation. HSBP1 may exert phosphorylation-activated functions linked with growth signaling pathways in unstressed cells. A homeostatic function at this level could protect cells from adverse effects of signal transduction systems which may be activated inappropriately during stress.
Synonyms CMT2F|HEL-S-102|HMN2B|HS.76067|HSP27|HSP28|Hsp25|SRP27
Reference Data
Protein Pathways MAPK signaling pathway, VEGF signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.